2019/11/27 by Mathias W. Hornef, Natalia Torow · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Diabetes and associated disorders #Immune Response and Inflammation #Reproductive System and Pregnancy
paper · pdf · doi:10.1111/imm.13149
crossref issued 2019/11/27 · crossref published 2019/11/27 · crossref published-online 2019/11/27 · openalex publication_date 2019/11/27 · crossref created 2019/11/28 · openalex created_date 2019/12/05 · crossref published-print 2020/01/01 · crossref deposited 2023/09/06 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31
The intricate host-microbial interaction and the overwhelming complexity of the mucosal immune system in the adult host raise the question of how this system is initially established. Here, we propose the implementation of the concept of the 'postnatal window of opportunity' into the model of a 'layered immunity' to explain how the newborn's mucosal immune system matures and how host-microbial immune homeostasis is established after birth. We outline the concept of a timed succession of non-redundant phases during postnatal immune development and discuss the possible influence of external factors and conditions.