2025/07/04 by Sohee Park, Sang Min Lee, Hye Jeon Hwang +3
Medicine · Physics and Astronomy · #Atomic and Subatomic Physics Research #Chronic Obstructive Pulmonary Disease (COPD) Research #Lung Cancer Diagnosis and Treatment
paper · doi:10.1093/bjr/tqaf105
crossref issued 2025/07/04 · crossref published 2025/07/04 · crossref published-online 2025/07/04 · openalex publication_date 2025/07/04 · crossref created 2025/07/04 · openalex created_date 2025/10/10 · crossref deposited 2026/07/22 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31 · crossref published-print 2026/08/01
Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous condition characterized by diverse pulmonary and extrapulmonary manifestations. Efforts to quantify its various components using CT imaging have advanced, aiming for more precise, objective, and reproducible assessment and management. Beyond emphysema and small airway disease, the two major components of COPD, CT quantification enables the evaluation of pulmonary vascular alteration, ventilation-perfusion mismatches, fissure completeness, and extrapulmonary features such as altered body composition, osteoporosis, and atherosclerosis. Recent advancements, including the application of deep learning techniques, have facilitated fully automated segmentation and quantification of CT parameters, while innovations such as image standardization hold promise for enhancing clinical applicability. Numerous studies have reported associations between quantitative CT parameters and clinical or physiologic outcomes in patients with COPD. However, barriers remain to the routine implementation of these technologies in clinical practice. This review highlights recent research on COPD quantification, explores advances in technology, and also discusses current challenges and potential solutions for improving quantification methods.