The many faces of mathematical modelling in oncology

2018/11/28 by Pedro Victori, Francesca M Buffa, Francesca M. Buffa
Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #Cancer Cells and Metastasis #Mathematical Biology Tumor Growth #Microtubule and mitosis dynamics

paper · doi:10.1259/bjr.20180856

openalex publication_date 2018/11/28 · crossref created 2018/11/28 · crossref issued 2018/12/17 · crossref published 2018/12/17 · crossref published-online 2018/12/17 · crossref published-print 2019/01/01 · crossref deposited 2024/05/02 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/07/31

Abstract

The application of modelling to solve problems in biology and medicine, and specifically in oncology and radiation therapy, is increasingly established and holds big promise. We provide an overview of the basic concepts of the field and its current state, along with new tools available and future directions for research. We will outline radiobiology models, examples of other anticancer therapy models, multiscale modelling, and we will discuss mechanistic and phenomenological approaches to modelling.

Citations

• Role of cell cycle in mediating sensitivity to radiotherapy
• The Cancer Genome Atlas Pan-Cancer analysis project

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