2007/08/01 by Hui Wang, Yao-Lan Li, Shen Wei-zai +5
Agricultural and Biological Sciences · Immunology and Microbiology · #Echinoderm biology and ecology #Immune Response and Inflammation #Seaweed-derived Bioactive Compounds
paper · doi:10.1515/bot.2007.022
crossref issued 2007/08/01 · crossref published 2007/08/01 · crossref published-print 2007/08/01 · openalex publication_date 2007/08/01 · crossref published-online 2007/08/10 · crossref created 2007/08/10 · crossref deposited 2022/04/10 · openalex created_date 2025/10/10 · crossref indexed 2026/07/27 · openalex updated_date 2026/07/28
Abstract An invasive green alga, Caulerpa racemosa , collected from the South China Sea was tested for its antiviral properties. Hot water extracts and the n -butanol fraction obtained showed potent inhibition of herpes simplex virus type 1 (HSV-1) and Coxsackie virus B3 (Cox B3). A sulfoquinovosyldiacylglycerol (SQDG) compound was isolated and purified from the n -butanol fraction following further antiviral-guided fractionation. The SQDG compound exhibited an excellent antiviral effect against HSV-2, with a 50% inhibitory concentration (IC 50 ) of 15.6 μg ml -1 against both standard and clinical strains of HSV-2, but showed only moderate antiviral effects against HSV-1 and Cox B3. The SQDG compound was chemically characterized using spectroscopic methods as (2 S )-1,2-di- O -palmitoyl-3- O -(6′-sulfo-α-D-quinovopyranosyl) glycerol. This is the first isolation from C. racemosa of this SQDG compound with notable selective antiviral activity against HSV-2.