The enzyme-free regioselective phosphorylation of ribonucleosides is promoted by metal ions

2026/01/01 by Manick Mistri, Biswarup Jash · 1 voice
Physics and Astronomy · Chemistry · Biochemistry, Genetics and Molecular Biology · #Origins and Evolution of Life #Cyclopropane Reaction Mechanisms #RNA and protein synthesis mechanisms

paper · doi:10.1039/d6ob00404k

openalex publication_date 2026/01/01 · openalex created_date 2026/05/13 · openalex updated_date 2026/07/25

Abstract

P NMR spectroscopy. Our current findings could help in bridging the gap between how reactive RNA precursors could have formed and how those precursors eventually emerged as the RNA chains needed for the origin of life.

Discussions

• Be sure to read research from Manick Mistri & Biswarup Jash at IIT Kharagpur in our latest issue showing how the enzyme-free regioselective phosphorylation of ribonucleosides is promoted by metal ions [bsky, 1 points, 0 comments]

Related

• Ribonucleotide Reductases
• In Vitro Selection of Functional Nucleic Acids
• Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes
• Understanding Nucleic Acids Using Synthetic Chemistry
• Nucleoside Phosphorylases Make N7-Xanthosine, the “Non-native” Regioisomer of Xanthosine