Is it bad, is it good, or is IgG4 just misunderstood?

2023/02/07 by Shiv Pillai · 1 voice · 1 citation
Immunology and Microbiology · Medicine · #Blood groups and transfusion #Complement system in diseases #Immunodeficiency and Autoimmune Disorders

paper · pdf · doi:10.1126/sciimmunol.adg7327

openalex publication_date 2023/02/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell–dependent elimination of infected cells (see related Research Article by Irrgang et al .).

Citations

• Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination

Cited by

• Classification bias and impact of COVID-19 vaccination on all-cause mortality: the case of the Italian region Emilia-Romagna

Discussions

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