Amphotericin B Induction with Voriconazole Consolidation as Salvage Therapy for FKS -Associated Echinocandin Resistance in Candida glabrata Septic Arthritis and Osteomyelitis

2019/07/24 by William F. Wright, Nika Bejou, Ryan K. Shields +3 · 1 voice
Medicine · #Antifungal resistance and susceptibility #Fungal Infections and Studies #Pneumocystis jirovecii pneumonia detection and treatment

paper · pdf · doi:10.1128/aac.00512-19

openalex publication_date 2019/07/24 · openalex created_date 2019/07/30 · openalex updated_date 2026/08/01

Abstract

We report the case of a 61-year-old female with Crohn’s disease dependent on total parenteral nutrition who developed a central venous catheter bloodstream infection and septic arthritis, complicated further by osteomyelitis and persistent Candida glabrata fungemia. Fluconazole treatment led to persistent infection, and micafungin therapy failed with development of FKS -associated resistance. Infection responded after initiation of amphotericin B plus voriconazole.

Discussions

• Very reasonable! However, is there any robust data to inform us on the optimal approach to FKS 1 and 2 hot spot mutations given there are even relapses with LAMB? Clin Infect Dis 56:1724–1732. doi: 10 [bsky, 2 points, 0 comments]

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