Borate-catalysed direct amidation reactions of coordinating substrates

2025/01/01 by Richard J. Procter, Carla Alamillo‐Ferrer, Usman Shabbir +7 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · #Antimicrobial Peptides and Activities #Chemical Synthesis and Analysis #Chemical Synthesis and Reactions

paper · pdf · doi:10.1039/d4sc07744j

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/02

Abstract

catalyst generation from commercially available reagents renders the process readily accessible for everyday laboratory use. Further experiments showed that the deactivating effect of 2-aminopyridine on boronic acid catalysts was due to its ability to stabilise catalytically inactive boroxines.

Citations

• A convenient n.m.r. method for the measurement of Lewis acidity at boron centres: correlation of reaction rates of Lewis acid initiated epoxide polymerizations with Lewis acidity

Discussions

• Our new borate amidation catalyst is now published in #ChemicalScience @roysocchem.bsky.social If you are making amides, it's super easy to try it out by generating the catalyst in situ from commerci [bsky, 2 points, 0 comments]

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