2024/08/16 by Madalena Gomes, Paul A.J. Krijnen, Esther Middelkoop +2 · 1 voice
Health Professions · Medicine · #Mesenchymal stem cell research #Pressure Ulcer Prevention and Management #Wound Healing and Treatments
paper · doi:10.1016/j.jid.2024.05.027
openalex publication_date 2024/08/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Fetal skin at early gestational stage is able to regenerate and heal rapidly after wounding. The exact mechanisms and molecular pathways involved in this process are however still largely unknown. The numerous differences in the skin of the early fetus versus skin in later developmental stages might provide clues for the mechanisms of scarless healing. This review summarizes the differences between mammalian fetal skin and the skin at later developmental phases in healthy and wounded conditions, focusing on extracellular matrix components, which are crucial factors in the microenvironment that direct cells and tissue functions and hence the wound healing process.