1988/08/01 by John D. Clemens, David A. Sack, Jeffrey R. Harris +12 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Escherichia coli research studies #Vibrio bacteria research studies #Viral gastroenteritis research and epidemiology
paper · doi:10.1093/infdis/158.2.372
openalex publication_date 1988/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/30
The B subunit (BS) of cholera toxin and that of the heat-labile enterotoxin (LT) of enterotoxigenic Escherichia coli (ETEC) are antigenically similar. We therefore assessed whether a combined cholera toxin BS/whole-cell (BS-WC) oral vaccine against cholera conferred cross-protection against LT-producing ETEC (LT-ETEC) diarrhea in a randomized, double-blind field trial among rural Bangladeshi children and women. The 24,770 persons who ingested two or more doses of BS-WC vaccine were compared with 24,842 controls who took two or more doses of killed whole-cell (WC) oral cholera vaccine. Sixty-seven percent fewer episodes of LT-ETEC diarrhea were noted in the BS-WC group than in the WC group during short-term (three-month) follow-up (P less than .01), but no reduction was evident during the ensuing nine months. Short-term protection was particularly notable against LT-ETEC diarrhea causing life-threatening dehydration (protective efficacy, 86%; P less than .05).