Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces

2025/02/21 by Dimitris Boufidis, Raghav Garg, Eugenia Angelopoulos +2 · 1 voice · 4 citations
Neuroscience · Engineering · #Neuroscience and Neural Engineering #Advanced Memory and Neural Computing #Photoreceptor and optogenetics research

paper · pdf · doi:10.1038/s41467-025-57016-0

openalex publication_date 2025/02/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering to realize biologically-active and/or cell-containing living layers at the tissue-device interface that enable seamless biointegration and novel cell-mediated therapeutic opportunities. This review maps the field of bio-inspired electronics and discusses key recent developments in tissue-like and regenerative bioelectronics, from soft biomaterials and surface-functionalized bioactive coatings to cell-containing 'biohybrid' and 'all-living' interfaces. We define and contextualize key terminology in this emerging field and highlight how biological and living components can bridge the gap to clinical translation.

Citations

• Neural probe design for reduced tissue encapsulation in CNS
• Neuronal ensemble control of prosthetic devices by a human with tetraplegia
• Axonal pathology in traumatic brain injury
• La protection des créanciers dans les fusions internationales de sociétés : droit international et comparé
• Skin-Inspired Electronics: An Emerging Paradigm
• Effects of extracellular matrix viscoelasticity on cellular behaviour
• A brain-computer interface that evokes tactile sensations improves robotic arm control
• High-performance brain-to-text communication via handwriting
• Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria
• Deep Brain Stimulation for Depression Informed by Intracranial Recordings
• Topological supramolecular network enabled high-conductivity, stretchable organic bioelectronics
• Walking naturally after spinal cord injury using a brain–spine interface
• Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

Cited by

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• Mycoelectronics: Bioprinted Living Fungal Bioelectronics for Artificial Sensation
• Enzyme-free in situ polymerization of conductive polymers catalyzed by porous Au@Ag nanowires for stretchable neural electrodes
• Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?

Discussions

• We discuss: 🔹Advances in tissue-like bioelectronics, from soft to biohybrid and all-living platforms 🔹How cell-containing technologies are redefining neural interfaces 🔹Key terminology for th [bsky, 2 points, 1 comments]

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