2025/02/01 by Inês Rosado Vitorino, José Diogo Neves dos Santos, Gloria Crespo +10 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Genomics and Phylogenetic Studies #Marine Sponges and Natural Products #Microbial Natural Products and Biosynthesis
paper · pdf · doi:10.1111/1751-7915.70076
openalex publication_date 2025/02/01 · openalex created_date 2025/02/25 · openalex updated_date 2026/07/31
ABSTRACT To address the on‐going need for chemical novelty and the limited information on Planctomycetota secondary metabolism, we focused on exploring the recently isolated marine planctomycetal strain Alienimonas chondri LzC2 T to uncover its potential production of novel compounds. This work contemplates the description of a large‐scale cultivation study of strain LzC2 T , followed by metabolite extraction and compound isolation using chromatographic approaches, which resulted in the isolation of a novel molecule designated as alichondrichlorin. Structural elucidation of this new molecule was accomplished by a combination of high‐resolution mass spectrometry and nuclear magnetic resonance. The molecule was additionally screened for anti‐proliferative bioactivity against human tumoral and non‐tumoral cell lines. These cytotoxicity assays revealed a targeted effect of alichondrichlorin in the growth of tumoral cell lines, especially human breast adenocarcinoma MCF‐7 cell line (EC 50 = 4.06 μM) without effect on the human non‐tumoral THLE‐2 cell line (EC 50 > 50 μM).