2025/03/20 by Justin Oh, Samir Patel, Mary-Pat Schlosser +4 · 1 voice
Medicine · #Brain Metastases and Treatment #Glioma Diagnosis and Treatment #Neuroblastoma Research and Treatments
paper · pdf · doi:10.3390/curroncol32030180
openalex publication_date 2025/03/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26
Radiation therapy (RT) is a cornerstone in the management of pediatric central nervous system (CNS) tumors. Recent advancements in RT delivery and techniques aim to enhance therapeutic effectiveness while minimizing both acute and long-term complications associated with pediatric brain RT. This paper highlights innovative developments in the field, including the clinical indications, benefits, and challenges of proton therapy and stereotactic radiotherapy. The ongoing refinement of risk-adapted RT volumes is highlighted, with examples of newly proposed germinoma RT volumes and hippocampal-sparing RT. Additionally, emerging experimental approaches, including FLASH therapy and theranostics, are also discussed as promising future directions. Further prospective, multi-institutional collaborative studies are essential to validate and expand upon the benefits outlined in this review.