2025/03/21 by Saburo Tsuru, Chikara Furusawa · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · #Gene Regulatory Network Analysis #Bioinformatics and Genomic Networks #RNA and protein synthesis mechanisms
paper · pdf · doi:10.1038/s41467-025-57642-8
openalex publication_date 2025/03/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The rate and direction of phenotypic evolution depend on the availability of phenotypic variants induced genetically or environmentally. It is widely accepted that organisms do not display uniform phenotypic variation, with certain variants arising more frequently than others in response to genetic or environmental perturbations. Previous studies have suggested that gene regulatory networks channel both environmental and genetic influences. However, how the gene regulatory networks influence phenotypic variation remains unclear. To address this, we characterize transcriptional variations in Escherichia coli under environmental and genetic perturbations. Based on the current understanding of transcriptional regulatory networks, we identify genetic properties that explain gene-to-gene differences in transcriptional variation. Our findings highlight the role of gene regulatory networks in shaping the shared phenotypic variability across different perturbations. Organisms display non-uniform transcriptional variability in response to genetic and environmental perturbations. This study on Escherichia coli reveals how gene regulatory networks shape transcriptional variability shared across different perturbations.