The structure of sodium thymonucleate fibres. I. The influence of water content

1953/09/10 by Rosalind Franklin, R.G. Gosling · 1 voice · 8 citations
Biochemistry, Genetics and Molecular Biology · #DNA and Nucleic Acid Chemistry

paper · pdf · doi:10.1107/s0365110x53001939

openalex publication_date 1953/09/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27

Abstract

A qualitative survey by Franklin & Gosling of the types of X-ray diagram given by highly orientated specimens of NaDNA at different humidities is reported. The structural changes which occur in NaDNA fibres when their water content is varied suggest that the fundamental structural unit is a group of molecules so arranged that the phosphate groups are exposed and accessible to water.

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Discussions

• The thing that blows my mind about using X-ray crystallography for DNA is that you have to condense the DNA into a paracrystalline gel and line up the fibers so you have some kind of order for the dif [bsky, 2 points, 0 comments]

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