Temporal and spatial omics technologies for 4D profiling

2025/04/22 by David E. Reynolds, Yoon Ho Roh, Daniel Oh +3 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Bioinformatics and Genomic Networks #Health, Environment, Cognitive Aging #Single-cell and spatial transcriptomics

paper · doi:10.1038/s41592-025-02683-6

crossref issued 2025/04/22 · crossref published 2025/04/22 · crossref published-online 2025/04/22 · openalex publication_date 2025/04/22 · crossref created 2025/04/22 · crossref published-print 2025/07/01 · crossref deposited 2025/09/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27 · crossref indexed 2026/07/27

Citations

• RNA velocity of single cells
• Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
• Nanomaterials: a review of synthesis methods, properties, recent progress, and challenges
• Bioorthogonal chemistry
• Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

Cited by

• Interpretation, extrapolation and perturbation of single cells
• Functional residuomics – analyzing how missense mutations impact cellular systems

Discussions

• This review chronicles and offers insights into the tremendous, ongoing journey towards the promising land of 4D profiling, which comprises 3D spatial omics with temporal monitoring. #spatialomics #t [bsky, 2 points, 0 comments]