Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance

2019/06/01 by Rebecca S. Moore, Rachel Kaletsky, Coleen T. Murphy · 1 voice · 4 citations
Biochemistry, Genetics and Molecular Biology · Psychology · #Genetics, Aging, and Longevity in Model Organisms #Neuroendocrine regulation and behavior

paper · pdf · doi:10.1016/j.cell.2019.05.024

crossref issued 2019/06/01 · crossref published 2019/06/01 · crossref published-print 2019/06/01 · openalex publication_date 2019/06/01 · crossref created 2019/06/06 · openalex created_date 2025/10/10 · crossref deposited 2026/05/13 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/29

Citations

• Defining trained immunity and its role in health and disease

Cited by

• Molecular requirements for C. elegans transgenerational epigenetic inheritance of pathogen avoidance
• Bridging the explanatory gaps: What can we learn from a biological agency perspective?
• Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes
• Trained innate immunity: Concept, nomenclature, and future perspectives

Discussions

• This builds on our previous findings that C. elegans loves the smell of pathogenic P. aeruginosa, but learns to avoid it, and then passes that learned avoidance on to four generations (!) of their pro [bsky, 2 points, 1 comments]