2025/02/24 by Mohammad Zagzoog, Ewa Tuleja, U. Michon-Pasturel +6 · 1 voice
Medicine · #Peripheral Artery Disease Management #Vascular Procedures and Complications #Venous Thromboembolism Diagnosis and Management
paper · pdf · doi:10.1177/1358863x251313964
openalex publication_date 2025/02/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/15
Introduction: Exercise transcutaneous oximetry (Ex-TcpO2) is used to support the vascular origin of lower-limb pain, or to assess walking impairment. The aim of this study was to describe the association between Ex-TcpO2 measurement and the perioperative clinical and morphological outcomes after revascularization in patients with intermittent claudication (IC). Methods: From January to December 2022, a single-center prospective observational study was conducted among patients with IC. Patients were referred by vascular surgeons for Ex-TcpO2 for doubtful arterial origin. Perioperative clinical and morphological outcomes were assessed by the Rutherford–Becker classification and duplex ultrasound examination. The primary patency rate and primary sustained clinical improvement were evaluated at 1 month after revascularization. Results: Eighty-two patients (64% men) underwent Ex-TcpO2 and were enrolled in the study, of whom 65% were category III of the Rutherford classification. Indications for Ex-TcpO2 were to assess the origin of the IC symptoms in 65%. Sixty-seven (81%) patients had positive Ex-TcpO2, and 15 (18%) had negative Ex-TcpO2. Patients with positive Ex-TcpO2 were older (65 ± 13 vs 58 ± 20, p = 0.43), and had a significantly lower ankle–brachial index (ABI) compared to the negative group (0.65 ± 0.22 vs 0.92 ± 0.22, p < 0.001) as well as a lower maximum walking distance (MWD) (200 m [150, 300] vs 525 m [500, 872], p < 0.001). Forty-two patients underwent revascularization (Ex-TcpO2 positive [ n = 35/67]; Ex-TcpO2 negative [ n = 7/15]). Revascularization technical success and primary patency rate were 100% in both groups. Clinical improvement was significantly greater in the Ex-TcpO2 positive group (97% [ n = 34/35] vs 0% [ n = 0/7], p < 0.001). Multivariate analysis shows a positive association between pain at the buttock and the decrease from rest of oxygen pressure (DROP) ≤ –15 mmHg at the level of the buttock with the presence of iliac lesions. Conclusion: On a routine basis, Ex-TcpO2 is a tool of interest to assess patients with claudication for doubtful arterial origin or walking distance, especially in proximal IC, and to predict favorable clinical outcomes after revascularization.