2024/12/17 by Manuel Praga, Fernando Caravaca‐Fontán, Iara Da Silva +4 · 1 voice
Medicine · #Renal Diseases and Glomerulopathies #Pregnancy and Medication Impact #Tuberous Sclerosis Complex Research
paper · doi:10.1093/ndt/gfae289
openalex publication_date 2024/12/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The treatment landscape for immunoglobulin A nephropathy is rapidly evolving with the introduction of novel therapies targeting diverse disease pathways. Some have already been approved in different countries, while others are under investigation in randomized controlled trials (RCTs) with encouraging results. However, almost all performed RCTs have included only patients with refractory non-nephrotic proteinuria and preserved renal function. Other clinical presentations (rapidly progressive forms, malignant hypertension, thrombotic microangiopathy, nephrotic syndrome) have received less attention and are systematically excluded from RCTs. In contrast, certain aspects, such as the impact of haematuria or management in special populations (e.g. pregnant patients or transplant recipients), remain underexplored. This review proposes therapeutic algorithms to guide treatment decisions in different clinical scenarios while highlighting gaps in current research.