2025/05/19 by MohammadHadi Bayat, Naheed Aryaeian, Fatemeh Shirani +5 · 1 voice
Agricultural and Biological Sciences · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Essential Oils and Antimicrobial Activity #Hops Chemistry and Applications #Rheumatoid Arthritis Research and Therapies
paper · doi:10.1016/j.jff.2025.106878
openalex publication_date 2025/05/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
In this randomized controlled double-blind clinical trial, 72 patients with rheumatoid arthritis were randomly assigned to two groups: one receiving rosemary leaf powder (4 g/day) and the other receiving a placebo (starch powder, 4 g/day). After 12 weeks of consuming rosemary leaf powder, significant changes were observed in disease activity score (DAS-28), tender joint count (TJC), swollen joint count (SJC), visual analog scale (VAS), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total antioxidant capacity, and malondialdehyde (MDA) between two groups ( p ≤ .001). Furthermore, there was no significant difference in morning stiffness ( p = .660), patient global assessment (PGA) ( p = .056), or tumor necrosis factor-alpha ( p = .751) serum levels between the two groups. However, in the group receiving rosemary powder, PGA and TNF-α serum levels decreased significantly (respectively, p = .001, p = .005). In patients with rheumatoid arthritis, rosemary supplements, when used alongside standard medications, may have beneficial effects.