Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis

2025/06/11 by Dylan Calhoon, Lingjie Sang, Fubo Ji +32 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer, Lipids, and Metabolism #Ferroptosis and cancer prognosis #RNA modifications and cancer

paper · doi:10.1038/s41586-025-09162-0

crossref issued 2025/06/11 · crossref published 2025/06/11 · crossref published-online 2025/06/11 · openalex publication_date 2025/06/11 · crossref created 2025/06/11 · crossref published-print 2025/08/21 · crossref deposited 2025/09/06 · openalex created_date 2025/10/10 · crossref indexed 2026/07/28 · openalex updated_date 2026/07/29

Citations

• Use of laurdan fluorescence intensity and polarization to distinguish between changes in membrane fluidity and phospholipid order

Cited by

• Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis

Discussions

• Lipidomics (& #METLIN) reveal a metabolic vulnerability in tumors @Nature doi.org/10.1038/s415... Tumors don’t just synthesize their own lipids—they scavenge antioxidant-rich lipoproteins. @JaviGBerm [bsky, 2 points, 0 comments]