Ketone ester ingestion impairs exercise performance without impacting cognitive function or circulating EPO during acute hypoxic exposure

2025/05/02 by Myrthe Stalmans, Domen Tominec, Wout Lauriks +4 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #High Altitude and Hypoxia #Diet and metabolism studies #Metabolomics and Mass Spectrometry Studies

paper · doi:10.1152/japplphysiol.00097.2025

openalex publication_date 2025/05/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

This study is the first to show that KE ingestion impairs exercise performance in hypoxia, at least when KE does not alleviate hypoxemia. Despite a subsequent, progressive increase in oxygenation upon KE after 3-4 h, this does not protect against hypoxia-induced cognitive declines. Although studies in normoxia show potential of KE to increase blood [erythropoietin], we identified that KE ingestion fails to augment the increase in blood [erythropoietin] through hypoxic exposure and exercise.

Citations

• Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms

Cited by

• Exploring the effects of exogenous ketosis on physiological adaptation to exercise in hypoxia(PhD Academy Award)
• Cerebral blood flow with exogenous ketosis: The full picture?

Discussions

• 📜 New publication available on ketone supplementation at altitude! "Ketone ester ingestion impairs exercise performance without impacting cognitive function or circulating EPO during acute hypoxic ex [bsky, 2 points, 1 comments]

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