2025/06/15 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Pluripotent Stem Cells Research #Epigenetics and DNA Methylation
paper · pdf · doi:10.1242/dev.205019
openalex publication_date 2025/06/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/09
Embryonic cells differentiate into two distinct lineages - the trophectoderm (TE), which constitutes the outer blastocyst layer and develops into the placenta, and the inner cell mass, which forms the embryo proper - during early mammalian development. In their study, Stanley Strawbridge and colleagues reveal that donor cells influence lineage specification in mice by sequentially excluding host cells through physical crowding and molecular signalling. To learn more about their work, we spoke to the first and corresponding author, Stanley Strawbridge, Group Leader and Early Career Research Fellow at University of Sheffield, UK.