Strategies for the Management of Cardiorenal Syndrome in the Acute Hospital Setting

2024/08/01 by Deepak Chandramohan, Prathap Simhadri, Nihar Jena +1 · 1 voice
Medicine · Engineering · #Heart Failure Treatment and Management #Electrolyte and hormonal disorders #Mechanical Circulatory Support Devices

paper · pdf · doi:10.3390/hearts5030024

openalex publication_date 2024/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

Cardiorenal syndrome (CRS) is a life-threatening disorder that involves a complex interplay between the two organs. Managing this multifaceted syndrome is challenging in the hospital and requires a multidisciplinary approach to tackle the many manifestations and complications. There is no universally accepted algorithm to treat patients, and therapeutic options vary from one patient to another. The mainstays of therapy involve the stabilization of hemodynamics, decongestion using diuretics or renal replacement therapy, improvement of cardiac output with inotropes, and goal-directed medical treatment with renin–angiotensin–aldosterone system inhibitors, beta-blockers, and other medications. Mechanical circulatory support is another viable option in the armamentarium of agents that improve symptoms in select patients.

Citations

• Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure
• When to use spironolactone, eplerenone or finerenone in the spectrum of cardiorenal diseases

Discussions

• Key Principles in Rx 1️⃣ Decongestion (diuretics/ultrafiltration). 2️⃣ Neurohormonal modulation (RAASI, SGLT2i). 3️⃣ Volume assessment (CVP, intrarenal Doppler). 4️⃣ Treat underlying systemic dise [bsky, 2 points, 1 comments]

Related

• Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association
• Cardiorenal Syndrome Revisited
• Cardiorenal Syndrome: Emerging Role of Medical Imaging for Clinical Diagnosis and Management
• Multimodal Strategies for the Diagnosis and Management of Refractory Congestion. An Integrated Cardiorenal Approach
• Novel Cardiometabolic Medications in the Cardiovascular-Kidney-Metabolic Syndrome Era