2025/06/23 by Nikita Sushentsev, Grégory Hamm, Roido Manavaki +14 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer, Lipids, and Metabolism #Prostate Cancer Diagnosis and Treatment #Prostate Cancer Treatment and Research
paper · pdf · doi:10.1073/pnas.2502423122
openalex publication_date 2025/06/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Cribriform prostate cancer (crPCa) is associated with poor clinical outcomes, yet its accurate detection remains challenging due to the poor sensitivity of standard-of-care diagnostic tools. Here, we use untargeted spatial metabolomics to identify fatty acid biosynthesis as a key metabolic pathway enriched in crPCa epithelium. We also show that imaging tumor lipid metabolism using [1- 11 C]acetate PET/CT and proton magnetic resonance spectroscopy differentiates cribriform from noncribriform intermediate-risk prostate cancers in two prospective patient cohorts. These findings support the feasibility of using clinical metabolic imaging techniques as adjunctive tools for improving crPCa detection in clinical practice, with prospective studies in larger cohorts warranted to obtain definitive results.