A cannabinoid receptor 1 inverse agonist induces weight loss and reduces airway hyperresponsiveness in a mouse model of obese asthma

2025/07/25 by Carolyn R. Morris, R Chandrasekaran, Isabella M. Butzirus +11 · 1 voice
Medicine · Neuroscience · #Cannabis and Cannabinoid Research #Dietary Effects on Health #Neuroscience of respiration and sleep

paper · doi:10.1152/ajplung.00049.2025

openalex publication_date 2025/07/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Inhibition of the cannabinoid receptor 1, through a pharmacological inverse agonist, not only induces weight loss in a mouse model of obese asthma but also reduces airway hyperresponsiveness, particularly through decreasing elastance/increasing compliance.

Discussions

• Publication alert 🚨Obese #asthma study on cannabinoid receptor offers contributions to future treatments, co-authored with #UVMLarnerMed faculty in Depts. of Medicine, Pathology, Anesthesiology, and [bsky, 2 points, 0 comments]

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