2025/08/01 by Ivan Đikić, Cristina Mayor‐Ruiz, Georg E. Winter +3 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · Computer Science · #Protein Degradation and Inhibitors #Radio Frequency Integrated Circuit Design #VLSI and Analog Circuit Testing
paper · pdf · doi:10.1016/j.molcel.2025.07.018
openalex publication_date 2025/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
In the past decade, exciting therapeutic strategies to harness the ubiquitin-proteasome system (UPS) for degradation of target proteins have emerged. Proximity-inducing modalities are at the center of these strategies and act by modulating protein-protein interactions. While we are still learning to harvest this approach, it holds tremendous promise for developing treatments for hitherto undruggable proteins. Here, we discuss how academic efforts and academic-industrial collaboration have advanced the development of therapeutic modalities based on the principle of proximity induction. We make a case for forming a global academia-industry alliance to enhance access to training and expertise while accelerating innovation and translation from ground-breaking ideas to proof of concept in the clinic.