2025/08/08 by Jinwen Wei, Huiru Zou, Qian-Yuan Tang +9 · 1 voice
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Neural dynamics and brain function #Neuroscience and Neural Engineering #Retinal Development and Disorders
paper · pdf · doi:10.1038/s42003-025-08600-z
openalex publication_date 2025/08/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Visual variability is linked to prestimulus alpha (8-13 Hz) and beta (13-30 Hz) power fluctuations, yet their causal role remains unclear. Using transcranial random noise stimulation (tRNS), we tested whether externally modulating cortical excitability could influence these oscillations and alter perception. In a sham-controlled, within-subject design, 29 participants completed a visual detection task combined with electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recordings. Mental fatigue was modelled as a state-dependent factor. tRNS, primarily under low fatigue, increased online oxyhemoglobin (HbO) amplitude, suppressed offline prestimulus alpha and beta power, and reduced offline visual contrast threshold (VCT), indicating enhanced perception. Further analyses revealed that fatigue influenced the oscillations' responsiveness to tRNS, and that under low fatigue, alpha power, more than beta, demonstrated greater functional sensitivity to VCT. These findings demonstrate that tRNS can improve perception by modulating alpha/beta oscillations in specific brain states, highlighting the role of brain state in neuromodulation efficacy.