2025/09/22 by Joel L. Pick, Craig A. Walling, Loeske E. B. Kruuk · 1 voice
Biochemistry, Genetics and Molecular Biology · #Genetic and phenotypic traits in livestock #Genetic diversity and population structure #Genetic Mapping and Diversity in Plants and Animals
paper · pdf · doi:10.1093/jeb/voaf104
openalex publication_date 2025/09/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/23
Maternal effects (the consistent effect of a mother on her offspring) can inflate estimates of additive genetic variation (VA) if not properly accounted for. As they are typically assumed to cause similarities only among maternal siblings, they are often accounted for by modelling maternal identity effects. However, if maternal effects have a genetic basis, they create additional similarities among relatives with related mothers that are not captured by maternal identity effects. Unmodelled maternal genetic variance (VMg) may therefore still inflate VA estimates in common quantitative genetic models, which is underappreciated in the literature. Using published data and simulations, we explore the extent of this problem. Published estimates from 8 species suggest that a large proportion of total maternal variation (VM) is genetic (∼65%). Both these data and simulations confirmed that unmodelled VMg can cause overestimation of VA and underestimation of VM, the bias increasing with the proportion of non-sibling maternal relatives in a pedigree. Simulations show these biases are further influenced by the size and direction of any direct-maternal genetic covariance. The estimation of total additive genetic variation (VAt; the weighted sum of VA and VMg) is additionally affected, limiting inferences about evolutionary potential from simple maternal effects models. Unbiased estimates require modelling VMg explicitly, but these models are often avoided due to perceived data limitations. We demonstrate that estimating VMg is possible even with small pedigrees, reducing bias in VA estimates, and maintaining accuracy in estimates of VA, VM, and VAt. We therefore advocate for the broader use of these models.