2024/01/01 by Anjana Rajeev, Sethuraman Muthuramalingam, Muniyandi Sankaralingam · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · #Asymmetric Hydrogenation and Catalysis #Chemical Synthesis and Analysis #Synthetic Organic Chemistry Methods
paper · pdf · doi:10.1039/d4ra05222f
openalex publication_date 2024/01/01 · openalex created_date 2024/09/25 · openalex updated_date 2026/07/03
-CPBA as the oxidant. In cyclohexane oxidation, catalysts showed activity (TON) in the order 1 (654) > 2 (589) > 3 (359) with a high A/(K + L) ratio up to 23.6. Using catalyst 1, the substrate scope of the reaction was broadened by including other cycloalkanes such as cyclopentane, cycloheptane, cyclooctane, adamantane and methylcyclohexane. Further, the Fenton-type reaction in the catalytic cycle was discarded based on the relatively high 3°/2° ratio of 8.6 in adamantane oxidation. Although the formation of chlorinated products during the reactions confirmed the contribution of the 3-chlorobenzoyloxy radical mechanism, the high alcohol selectivity obtained for the reactions indicated the participation of nickel-based oxidants in the oxidation process.