2025/10/07 by Tanmayee Narendra, Giovanni Visonà, Crhistian de Jesus Cardona +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Epigenetics and DNA Methylation #Genomics and Chromatin Dynamics #Machine Learning in Bioinformatics
paper · doi:10.1093/nargab/lqaf188
openalex publication_date 2025/10/07 · openalex created_date 2025/12/21 · openalex updated_date 2026/07/30
Epigenetic mechanisms enable cellular differentiation and the maintenance of distinct cell types. They enable rapid responses to external signals through changes in gene regulation and their registration over longer time spans. Consequently, the chromatin landscape, which is the overall organization and biochemical state of chromatin, exhibits both cell-type and individual specificity and contributes to phenotypic diversity. Genomic distributions of chromatin features are typically measured using chromatin immunoprecipitation sequencing and related methods. However, these measurements are subject to substantial biases introduced by the chromatin landscape itself. Here, we introduce DecoDen, which uses measurements of several different histone modifications, to simultaneously learn shared chromatin landscapes while de-biasing individual measurement tracks. We demonstrate DecoDen's effectiveness on an integrative analysis of histone modification patterns across multiple tissues in personal epigenomes. DecoDen is available at https://github.com/ntanmayee/decoden.