2025/01/01 by Sunjie Yang, Zedong Wang, Ruixin Guo +1 · 1 voice
Agricultural and Biological Sciences · Medicine · #Animal Disease Management and Epidemiology #Mosquito-borne diseases and control #Viral Infections and Vectors
paper · doi:10.1016/j.dcit.2025.100045
openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Alongshan virus (ALSV) is an emerging tick-borne segmented RNA virus belonging to the Flaviviridae family, first identified in Northeastern China in 2017. ALSV is currently classified within the Jingmenvirus group, which includes other segmented flavi-like viruses. Since its discovery, ALSV has been detected in various regions, including China, Russia, and several European countries, highlighting its expanding geographic distribution. This review summarizes the latest research progress on ALSV, focusing on its pathogenic characteristics, pathogenicity, epidemiological features, and detection methods. ALSV exhibits a segmented genome, unique structural and nonstructural proteins, and potential neurotropism, with clinical symptoms resembling other tick-borne diseases. Detection methods, including nucleic acid detection and high-throughput sequencing, have advanced ALSV research, though challenges remain in standardization and clinical application. Understanding ALSV's ecological characteristics, transmission mechanisms, and public health impact is crucial for developing effective prevention and control strategies. This review provides valuable insights for healthcare institutions and policymakers to mitigate ALSV's risks. • Comprehensively elucidates Alongshan virus's etiological features and explore molecular mechanisms driving pathogenicity. • Review Alongshan virus's global spatiotemporal spread, transmission routes, and tick-host epidemiological dynamics. • Provides a systematic summary and comparative analysis of various approaches for the detection of the Alongshan virus.