Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity

2025/08/30 by Daniel R. Machin, Md Torikul Islam, Alec Malouf +8 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Cardiovascular and exercise physiology #High Altitude and Hypoxia #Sports Performance and Training

paper · pdf · doi:10.18632/aging.206313

openalex publication_date 2025/08/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03

Abstract

-treated old mice. Collectively, these findings suggest that glycocalyx integrity is a critical determinant of physical function and that glycocalyx-targeted interventions may be a viable therapeutic strategy to treat age-related physical dysfunction.

Discussions

• 🔆 #PaperSpotlight: A new #research paper was recently #published on August 30 in Volume 17, Issue 9, titled “Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exerc [bsky, 2 points, 0 comments]

Related

• Longitudinal Decline of Exercise Capacity in Male and Female Mice
• The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise
• N-acetylcarnosine attenuates age-associated declines in multi-organ systems to improve survival
• Body-wide multi-omic counteraction of aging with GLP-1R agonism
• Gasdermin E: a missing link in muscle regeneration