2025/10/12 by Eden Mama, Rona Shaharabani, José P. Marques +1 · 1 voice
Materials Science · Medicine · #Advanced MRI Techniques and Applications #Lanthanide and Transition Metal Complexes #MRI in cancer diagnosis
paper · pdf · doi:10.1002/mrm.70096
openalex publication_date 2025/10/12 · openalex created_date 2025/10/13 · openalex updated_date 2026/07/15
PURPOSE: Water fraction (WF) estimation, a form of quantitative MRI mapping, is typically performed using the variable flip angle (VFA) approach. In this study, WF estimation was extended to include the magnetization prepared with 2 rapid gradient echoes (MP2RAGE) protocol. The two methods were compared to assess the consistency of WF values across both acquisition strategies. METHODS: maps were calculated using both the VFA and MP2RAGE acquisition protocols. In vivo and phantom datasets were used to assess the comparability of WF estimation between the two methods. Repeatability and reproducibility were evaluated both within each acquisition approach and across the two protocols. RESULTS: maps derived from the VFA and MP2RAGE approaches. The extraction of WF maps from the MP2RAGE protocol was validated, and the consistency of WF estimation across both methods was confirmed. CONCLUSION: maps derived from both the VFA and MP2RAGE methods. The ability to obtain reliable WF estimates from either protocol expands the applicability of WF mapping across a broader range of imaging studies.