2025/09/15 by Margot Tesselaar, Stefano Partelli, Arthur J. A. T. Braat +7 · 1 voice
Medicine · #Lung Cancer Research Studies #Neuroendocrine Tumor Research Advances #Pancreatic and Hepatic Oncology Research
paper · doi:10.1111/jne.70083
openalex publication_date 2025/09/15 · openalex created_date 2025/09/16 · openalex updated_date 2026/07/22
Locally advanced neuroendocrine neoplasms (NENs) are defined by extensive local invasion in the absence of distant metastases, although specific definitions may vary among study groups. While most patients with NENs present with localized or metastatic disease, a smaller subset is diagnosed with locally advanced tumors. Management of this subgroup remains particularly challenging, owing to the limited evidence base and lack of consensus regarding optimal therapeutic strategies. This guidance document synthesizes the current evidence and expert knowledge on the management of locally advanced NENs of the small intestine and pancreas, addressing four clinically relevant key questions that aim to inform best practice in these patients.