2018/08/31 by Bogna Grygiel-Górniak, Bogna Grygiel‐Górniak, Natalia Rogacka +1
Medicine · #Celiac Disease Research and Management #Monoclonal and Polyclonal Antibodies Research #Systemic Lupus Erythematosus Research
paper · pdf · doi:10.5114/reum.2018.77976
crossref issued 2018/08/31 · crossref published 2018/08/31 · crossref published-online 2018/08/31 · crossref published-print 2018/08/31 · openalex publication_date 2018/08/31 · crossref created 2018/09/18 · crossref deposited 2023/01/27 · openalex created_date 2025/10/10 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/29
The presence of antinuclear antibodies (ANA) is mainly associated with connective tissue diseases (CTD). In addition, their presence is found in healthy people. These antibodies are more common in women and the elderly. Some drugs and xenobiotics are also important for the development of autoimmunity and ANA synthesis. Moreover, the deficiency of vitamin D in the body of patients correlates with occurrence of these antibodies. Unlike the healthy group, a positive ANA count was observed in patients with atopic dermatitis (AD) and in people with immune disorders. Antinuclear antibodies in low counts are also found in the course of chronic bacterial or viral infection and in patients with hematological malignancies. Also the possibility of false positive results, which may be caused by the choice of method used to determine antibodies, should be borne in mind. Taking into account all these factors, it is concluded that the ANA result itself has no diagnostic value.