2022/07/20 by Karl Friston, Guillaume Flandin, Adeel Razi · 1 voice
Mathematics · Medicine · #COVID-19 epidemiological studies #Data-Driven Disease Surveillance #Influenza Virus Research Studies
paper · pdf · doi:10.1038/s41598-022-16799-8
openalex publication_date 2022/07/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
This technical report describes the dynamic causal modelling of mitigated epidemiological outcomes during the COVID-9 coronavirus outbreak in 2020. Dynamic causal modelling is a form of complex system modelling, which uses 'real world' timeseries to estimate the parameters of an underlying state space model using variational Bayesian procedures. Its key contribution-in an epidemiological setting-is to embed conventional models within a larger model of sociobehavioural responses-in a way that allows for (relatively assumption-free) forecasting. One advantage of using variational Bayes is that one can progressively optimise the model via Bayesian model selection: generally, the most likely models become more expressive as more data becomes available. This report summarises the model (on 6-Nov-20), eight months after the inception of dynamic causal modelling for COVID-19. This model-and its subsequent updates-is used to provide nowcasts and forecasts of latent behavioural and epidemiological variables as an open science resource. The current report describes the underlying model structure and the rationale for the variational procedures that underwrite Bayesian model selection.