Proteomic and functional analysis on endothelial cell heterogeneity identifies key regulators in hyperglycemia-induced dysfunction

2025/11/11 by Morgan Minjares, Ruchi Jaiswal, Hainan Li +4 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Angiogenesis and VEGF in Cancer #Cell Adhesion Molecules Research #Wound Healing and Treatments

paper · doi:10.1152/ajpcell.00273.2025

openalex created_date 2025/11/11 · openalex publication_date 2025/11/11 · openalex updated_date 2026/07/27

Abstract

Our research highlights the functional and proteomic differences between human aortic endothelial cells (HAECs) and human dermal microvascular endothelial cells (HDMVECs). Importantly, we identified WARS1 as a novel target in HDMVECs. Together with SOD2, correcting the abnormalities of these two molecules, HDMVECs' migration and permeability can be fine-tuned under high glucose (HG) conditions. Furthermore, WARS1 knockdown and SOD2 overexpression accelerated wound healing in type 2 diabetic mice, highlighting the therapeutic potential of targeting WARS1 and SOD2 to address delayed wound healing in diabetes.

Citations

• Adaptive linear step-up procedures that control the false discovery rate

Discussions

• Wayne State EACPHS shows microvascular ECs are more vulnerable to high-glucose stress. 🔗 doi.org/10.1152/ajpc... #Diabetes #VascularBiology #Proteomics [bsky, 2 points, 0 comments]

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