Direct oral amoxicillin challenge in a tertiary care center: validating PEN-FAST in inpatient and outpatient populations with low-risk penicillin allergies

2025/01/01 by Natalie Harris, Nicholas A. Turner, Amy Mackowiak +1 · 1 voice
Medicine · #Contact Dermatitis and Allergies #Drug-Induced Adverse Reactions #Food Allergy and Anaphylaxis Research

paper · pdf · doi:10.1017/ash.2025.10168

openalex publication_date 2025/01/01 · openalex created_date 2025/12/10 · openalex updated_date 2026/05/21

Abstract

Ten percent of hospitalized patients have documented penicillin allergies, over 90% of which are mislabeled and lead to the use of less-preferred alternative antibiotics. The results of this single-center review provide an outlook at successes and opportunities for improvement with the use of an amoxicillin oral challenge for allergy de-labeling.

Discussions

• One of the few real-world validations of PEN-FAST in hospitalized and clinic patients. In this evaluation of direct oral amoxicillin challenge for low-risk penicillin allergies, 95.7% tolerated the ch [bsky, 2 points, 0 comments]

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