Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production

2026/01/16 by Kimberly S. Huggler, Kyle M. Flickinger, Matthew H. Forsberg +6 · 1 voice
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #Cancer, Hypoxia, and Metabolism #Mitochondrial Function and Pathology

paper · doi:10.1038/s42255-025-01428-1

crossref issued 2026/01/16 · crossref published 2026/01/16 · crossref published-online 2026/01/16 · openalex publication_date 2026/01/16 · crossref created 2026/01/16 · openalex created_date 2026/01/17 · crossref deposited 2026/01/29 · crossref indexed 2026/06/30 · openalex updated_date 2026/07/23

Citations

• Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
• Metabolite Spectral Accuracy on Orbitraps
• The Warburg Effect: How Does it Benefit Cancer Cells?
• The Genotype-Tissue Expression (GTEx) project

Discussions

• 3. A new @natmetabolism.nature.com publication from multi-time ACS grantee Dr. @jasonrcantor.bsky.social & team @morgridgeinstitute.bsky.social showing detachment of hexokinase from outer mitochondria [bsky, 2 points, 1 comments]