Structure and mechanism of the human bile acid transporter OSTα–OSTβ

2026/01/28 by Ke Wang, Junping Fan, Huiwen Chen +9 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Amino Acid Enzymes and Metabolism #Drug Transport and Resistance Mechanisms #Ion Transport and Channel Regulation

paper · doi:10.1038/s41586-025-09934-8

crossref issued 2026/01/28 · crossref published 2026/01/28 · crossref published-online 2026/01/28 · openalex publication_date 2026/01/28 · crossref created 2026/01/28 · openalex created_date 2026/01/29 · crossref published-print 2026/03/05 · crossref deposited 2026/03/05 · crossref indexed 2026/07/21 · openalex updated_date 2026/07/29

Citations

• CHARMM‐GUI: A web‐based graphical user interface for CHARMM
• UCSF ChimeraX: Structure visualization for researchers, educators, and developers
• Highly accurate protein structure prediction with AlphaFold
• UCSF Chimera—A visualization system for exploratory research and analysis

Discussions

• The work reveals a unique dimer-of-heterodimers architecture and the structural basis of bile acid binding and transport, advancing our understanding of #BileAcid homeostasis and cholestasis. doi.org [bsky, 2 points, 0 comments]