Divergent housane synthesis via intramolecular [2 + 2] cycloaddition of 1,4-dienes

2026/02/19 by Fuhao Zhang, Julius Domack, Niklas Hölter +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · #Plant biochemistry and biosynthesis #Synthesis and Properties of Aromatic Compounds #Traditional and Medicinal Uses of Annonaceae

paper · doi:10.1038/s44160-026-00997-7

crossref issued 2026/02/19 · crossref published 2026/02/19 · crossref published-online 2026/02/19 · openalex created_date 2026/02/19 · openalex publication_date 2026/02/19 · crossref created 2026/02/19 · crossref deposited 2026/06/10 · crossref indexed 2026/07/09 · openalex updated_date 2026/07/29

Citations

• Intermolecular [2π+2σ]-photocycloaddition enabled by triplet energy transfer
• Reaction development: a student's checklist
• Stereoselective Synthesis of Highly Functionalized Bicyclo[2.1.0]pentanes by Sequential [2 + 1] and [2 + 2] Cycloadditions
• Highly stereoselective synthesis of polysubstituted housanes and spiro-oxa-housanes: application and mechanistic insights

Discussions

• Thrilled to share that our work on a divergent strategy for housane synthesis via intramolecular energy-transfer [2+2] cycloaddition of 1,4-dienes is now published in @natsynth.nature.com 🚀 link to [bsky, 2 points, 0 comments]