2026/02/01 by Minzhi Jiang, Changyu Wang, Kai Wang +10 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Berberine and alkaloids research #Helicobacter pylori-related gastroenterology studies #Synthesis and Biological Activity
paper · pdf · doi:10.1002/mlf2.70061
openalex publication_date 2026/02/01 · openalex created_date 2026/02/19 · openalex updated_date 2026/07/23
Impact statement Helicobacter pylori is a major gastric pathogen with increasing antibiotic resistance, creating an urgent need for new therapeutic strategies. We screened 37 pure compounds and 9 herbal extracts for anti‐ H. pylori activity and identified berberrubine as the most potent agent, with a minimum inhibitory concentration of 11 μg/ml. Berberrubine exhibited bacteriostatic effects by inducing oxidative stress and disrupting membrane integrity, as demonstrated by transcriptomic analysis, reactive oxygen species (ROS) accumulation, and structural damage, all of which were alleviated by the antioxidant N‐acetylcysteine. Similar inhibitory effects were observed in Escherichia coli , indicating broader antimicrobial potential. This study provides the mechanistic evidence of berberrubine's activity against H. pylori , highlighting its promise as a candidate for development into alternative therapies to address antibiotic resistance.