2026/04/21 by Luisa Fernanda Gomez-Alatorre, Alon Amir, Mohamed Badawy +2 · 1 voice
Neuroscience · #Neural and Behavioral Psychology Studies #Memory and Neural Mechanisms #Neural dynamics and brain function
paper · doi:10.1016/j.bbrc.2026.153825
openalex publication_date 2026/04/21 · openalex created_date 2026/04/22 · openalex updated_date 2026/07/17
Human fMRI studies suggest that the anterior insula (AIC) encodes salience and deviations from expectations. However, BOLD signals have insufficient resolution to determine how AIC cells encode these variables. To study this question, rats were presented with auditory stimuli that varied from rewarding to aversive, instilling expectations that were later confirmed or challenged. Most AIC neurons showed significant task-related activity, either in the form of motor correlates, responses to appetitive or noxious sounds, in anticipation of reward delivery, or a combination of these factors. There was extensive overlap between neurons excited by the noxious and appetitive stimuli. Yet, stimuli with the highest positive and negative valence excited more AIC neurons than stimuli with intermediate valence, consistent with the signaling of salience. Strikingly, the responses of AIC cells to stimuli that confirmed reward expectations decreased whereas responses to stimuli that challenged reward expectations increased, akin to an unsigned prediction error signal.