2024/03/21 by Yuxin Liu, Wei Zheng, Jieying Zhang +7 · 1 voice
Engineering · Materials Science · #Nanoplatforms for cancer theranostics #Luminescence Properties of Advanced Materials #Advanced Nanomaterials in Catalysis
paper · pdf · doi:10.1002/adma.202402981
openalex publication_date 2024/03/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
The photothermal therapeutic effect on tumors located at different subcutaneous depths varies due to the attenuation of light by tissue. Here, based on the wavelength-dependent optical attenuation properties of tissues, the tumor depth is assessed using a multichannel lanthanide nanocomposite. A zeolitic imidazolate framework (ZIF-8)-coated nanocomposite is able to deliver high amounts of the hydrophilic heat shock protein 90 inhibitor epigallocatechin gallate through a hydrogen-bonding network formed by the encapsulated highly polarized polyoxometalate guest. It is superior to both bare and PEGylated ZIF-8 for drug delivery. With the assessment of tumor depth and accumulated amount of nanocomposite by fluorescence, an irradiation prescription can be customized to release sufficient HSP90 inhibitor and generate heat for sensitized photothermal treatment of tumors, which not only ensured therapeutic efficacy but also minimized damage to the surrounding tissues.