l-Proline Alters Energy Metabolism in Brain Cortical Tissue Slices

2024/11/18 by Abhijit Das, Gregory Gauthier-Coles, Stefan Bröer +2 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Amino Acid Enzymes and Metabolism #Mitochondrial Function and Pathology #Neuroscience and Neuropharmacology Research

paper · doi:10.1007/s11064-024-04262-1

crossref issued 2024/11/18 · crossref published 2024/11/18 · crossref published-online 2024/11/18 · openalex publication_date 2024/11/18 · crossref created 2024/11/18 · crossref published-print 2025/02/01 · crossref deposited 2025/02/01 · openalex created_date 2025/10/10 · crossref indexed 2026/05/27 · openalex updated_date 2026/07/23

Citations

• Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
• Behavioral and neurochemical effects of proline
• Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes.

Cited by

• Glutamine transport via amino acid transporter NTT4 (SLC6A17) maintains presynaptic glutamate supply at excitatory synapses in the CNS

Discussions

• Just published a little paper about the role of L-Proline in brain metabolism. It stimulates mitochondrial metabolism but doesn't seem to do it by being metabolised (under the conditions studied). Yet [bsky, 3 points, 0 comments]