Animal Models of Proliferative Vitreoretinopathy and Their Use in Pharmaceutical Investigations

2018/01/01 by Huiyuan Hou, Eric Nudleman, Robert N. Weinreb +1
Biochemistry, Genetics and Molecular Biology · Medicine · #Drug-Induced Ocular Toxicity #Retinal Development and Disorders #Retinal and Macular Surgery

paper · doi:10.1159/000488492

crossref issued 2018/01/01 · crossref published 2018/01/01 · crossref published-print 2018/01/01 · openalex publication_date 2018/01/01 · crossref published-online 2018/05/03 · crossref created 2018/05/03 · crossref deposited 2025/04/23 · openalex created_date 2025/10/10 · crossref indexed 2026/07/25 · openalex updated_date 2026/07/26

Abstract

Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.

Citations

• TGF-β1-mediated fibroblast–myofibroblast terminal differentiation—the role of smad proteins
• Pathogenic Mechanisms in Proliferative Vitreoretinopathy

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