2025/02/15 by Emad Gamil Khidr, Nourhan Ibrahim Morad, Shymaa Hatem +7
Agricultural and Biological Sciences · Medicine · #Natural Antidiabetic Agents Studies #Pharmacology and Obesity Treatment #Phytochemistry Medicinal Plant Applications
paper · pdf · doi:10.1007/s00210-025-03866-w
crossref issued 2025/02/15 · crossref published 2025/02/15 · crossref published-online 2025/02/15 · openalex publication_date 2025/02/15 · crossref created 2025/02/15 · crossref published-print 2025/07/01 · crossref deposited 2025/09/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29 · crossref indexed 2026/07/31
Diabetic retinopathy (DR) represents a significant and serious complication associated with diabetes mellitus (DM), often resulting in considerable visual impairment or even blindness. The intricate pathological processes underlying DR complicate the effectiveness of current treatment modalities. Studies have highlighted the potential of natural products in the treatment of DR via several beneficial effects including anti-inflammatory, antioxidant, anti-neovascular, and anti-apoptotic properties. Flavonoids, saponins, saccharides, and alkaloids exhibited various beneficial effects in DR in in vivo and in vitro studies. However, the clinical utilization of these natural compounds is hindered by issues such as inadequate specificity, low bioavailability, and potential toxicity. Therefore, there is a pressing need for rigorous clinical studies to confirm the efficacy of natural products in preventing or mitigating the progression of DR.