2016/08/29 by Chiara Sulpizio, Simon T. R. Müller, Qi Zhang +2
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Genomics, phytochemicals, and oxidative stress #Ginseng Biological Effects and Applications #Pharmacological Effects of Natural Compounds
paper · pdf · doi:10.1007/s00706-016-1822-7
crossref issued 2016/08/29 · crossref published 2016/08/29 · crossref published-online 2016/08/29 · openalex publication_date 2016/08/29 · crossref created 2016/08/29 · openalex created_date 2016/09/16 · crossref published-print 2016/11/01 · crossref deposited 2017/06/24 · crossref indexed 2026/07/27 · openalex updated_date 2026/07/28
Four new metal complexes [Cu(ISO)2], [Cu(BUT)2] and [Zn(ISO)2], [Zn(BUT)2] of the polyhydroxychalcones (isoliquiritigenin and butein) are synthesized, structurally characterized and their antioxidant activity is investigated. The formation of the complexes [Cu(ISO)2] and [Zn(ISO)2] is followed by Job’s plot using NMR titration. The resulting compounds are characterized by mass spectrometry, IR spectroscopy, and elemental analysis. Studies on the radical scavenging activity are performed using DPPH as substrate. The results showed that the antioxidant activities of isoliquiritigenin and butein are enhanced after binding to copper or zinc. Graphical abstract