2019/10/29 by Sara N. Hall, Henry D. Appelman
Medicine · #Helicobacter pylori-related gastroenterology studies #Liver Diseases and Immunity #Microscopic Colitis
paper · pdf · doi:10.5858/arpa.2019-0345-ra
openalex publication_date 2019/10/29 · crossref created 2019/10/29 · crossref issued 2019/11/01 · crossref published 2019/11/01 · crossref published-print 2019/11/01 · openalex created_date 2025/10/10 · crossref deposited 2025/12/03 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31
CONTEXT.—: Autoimmune gastritis (AG) is a corpus-restricted chronic atrophic gastritis associated with intrinsic factor deficiency, either with or without pernicious anemia. Autoimmune gastritis is a microscopic disease because patients present with no or vague symptoms, and clinicians rarely find endoscopic changes. Autoimmune gastritis only becomes a clinical disease when pathologists diagnose it in gastric biopsies performed for a variety of clinical indications. Unfamiliarity with this disease can result in misdiagnosis of patients, and thus inadequate patient management. OBJECTIVE.—: To review the pathogenesis, clinical features, diagnostic criteria, differential diagnoses, sequelae, and surveillance recommendations for AG. DATA SOURCES.—: The sources of the study include a review of the pertinent literature for AG. CONCLUSIONS.—: Autoimmune gastritis is an important disease characterized by a loss of oxyntic mucosa and presence of metaplastic epithelium and enterochromaffin-like cell hyperplasia. Awareness and proper diagnosis are critical to prevent mismanagement of patients.